The Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used to control pain, fever
and inflammation. Although the benefits obtained from the use of NSAIDs are important,
around 25% of people who use such drugs have side effects, which limit their use. From
this principle, the study aimed to evaluate the gastrointestinal and renal side effects after
the use of anti-inflammatory Trometamol, and compare with the most commonly used
anti-inflammatory drugs: Ketoprofen and Diclofenac Sodium. The type of study used to
resolve the problem was an experimental comparative applied. Sub chronic doses of the
drugs were administered in 28 Wistar rats divided into 4 groups. We analyzed stomach
ulcer index, blood count and creatinine tests and histopathological analyzes of renal
structure. The Trometamol and Ketoprofen were drugs that caught more attention when we
see the graphics, because their rates of minor damage were higher in most graphics (RBCs,
ulcer index, platelets and leukocytes). The difference between the four experimental
groups was not large, so the medicines may be used at doses sub-chronic during a period of
15 days, without causing severe side effects. However, the problems caused per these
drugs are proven and users of NSAIDs should always be alert to a possible damage to the
body. However, these medicine were shown that they can cause serious damage to the
gastrointestinal and renal systems.
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