Alteração mastigatória, ambiente enriquecido e envelhecimento: estudos estereológicos de ca1 do hipocampo do camundongo suíço albino.
To investigate possible influences of enriched environment on the changes of CA1 astrocytic laminar distribution induced by reduced mastication, female albino Swiss mice fed with soft diet (SD) or hard diet (HD) were housed from weaning either in impoverished conditions or in enriched condition...
| Autor principal: | FELÍCIO, André Pinheiro Gurgel |
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| Outros Autores: | MENDES, Fabíola de Carvalho Chaves de Siqueira |
| Grau: | Trabalho de Conclusão de Curso - Graduação |
| Publicado em: |
2022
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| Assuntos: | |
| Acesso em linha: |
https://bdm.ufpa.br:8443/jspui/handle/prefix/4849 |
| Resumo: |
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To investigate possible influences of enriched environment on the changes of CA1 astrocytic
laminar distribution induced by reduced mastication, female albino Swiss mice fed with soft
diet (SD) or hard diet (HD) were housed from weaning either in impoverished conditions or
in enriched conditions. After 6, 12 and 18 months brain hippocampal sections from both HD
and SD animals were immunolabeled for glial fibrillary acid protein to identify astrocytes and
a blind optical fractionator’s analysis was applied to assess possible changes in the laminar
distribution. SD as compared to HD stereological estimations revealed that the laminar
distribution of astrocytes in CA1 was differentially affected by reduced mastication and aging
and these variables seem to produce addictive effects. Apart from stratum pyramydale where
enriched environment seem to increase aging and masticatory effects of reduction in the
number of astrocytes, in all other layers enriched environment seems to counteract the impact
of masticatory deprivation and aging. Thus, differential effects on CA1 astrocytic laminar
distribution were found as a function of masticatory deprivation, age and environment
suggesting that at least two different profiles of astrocytes may be contributing to these
events. Possible molecular mechanisms associated to these differences remain to be
investigated. |