Artigo

Solução numérica do modelo neuronal de Hodgkin-Huxley

In 1952, Alan Hodgkin and Andrew Huxley published a paper in which they presented a model consisting of a system of nonlinear ordinary differential equations that described how action potentials (electrical signals that carry information from one place to another in the nervous system) are genera...

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Autor principal: COSTA, Danielle Baia da
Grau: Artigo
Publicado em: 2023
Assuntos:
Acesso em linha: https://bdm.ufpa.br:8443/jspui/handle/prefix/4924
Resumo:
In 1952, Alan Hodgkin and Andrew Huxley published a paper in which they presented a model consisting of a system of nonlinear ordinary differential equations that described how action potentials (electrical signals that carry information from one place to another in the nervous system) are generated and propagated. In this work, the objective is to solve the Hodgkin-Huxley model numerically in order to obtain information that will help in the understanding of this phenomenon. For this, the fourth-order Runge-Kutta method was used. The results obtained showed that the opening, closing and permeation properties of voltage-dependent ion channels allow the generation of action potentials, which is nothing more than the inversion of the resting potential of the neuron membrane, where its interior is makes it more positively charged in relation to the outside. Based on this result, it was concluded that changes in the properties of ion channels affect the emergence of action potentials and, consequently, the functioning of the neuron.