Prevalência de anticorpos antifosfolipídios em mães de recém nascidos prematuros nascidos na Fundação Santa Casa de Misericórdia Do Pará no período de julho a setembro de 2007
The Antiphospholipid antibodies are a family of antibodies responsible for the Antiphospholipid Antibody Syndrome. The occurrence of this disorder during pregnancy is related with recurrent pregnancy loss, intra-uterine growth restriction and preterm delivery. The authors studied the prevalence of a...
| Autor principal: | DRAGO, Gilmário Fernandes |
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| Outros Autores: | AZEVEDO, Luciana Silveira Nina de |
| Grau: | Trabalho de Conclusão de Curso - Graduação |
| Publicado em: |
2023
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| Assuntos: | |
| Acesso em linha: |
https://bdm.ufpa.br:8443/jspui/handle/prefix/4971 |
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The Antiphospholipid antibodies are a family of antibodies responsible for the Antiphospholipid Antibody Syndrome. The occurrence of this disorder during pregnancy is related with recurrent pregnancy loss, intra-uterine growth restriction and preterm delivery. The authors studied the prevalence of antiphospholipid antibodies in 80 mothers of preterm newborns and 40 mothers of term newborns, to get the laboratory analysis as well as a clinical and epidemiological profile of the mothers and newborns selected. The anticardiolipin antibody/IgM was observed in 3.75%. When the analysis was restricted only for the cases where the birth occurred until the 34th week of pregnancy there was a prevalence of 10.71%. It was not possible to establish correlation between the levels of antibodies and the progression of the gestational age. The lupus anticoagulant and anticardiolipin antibody/IgG were not found in the samples analyzed. The average age of mothers in the term group was 23.4 years old as long as among the preterms the average was 22.4 years old. The average gestational age of preterm newborns was 34 weeks and in the term group it was 39 weeks. Smoking was present in 12.5% in the term group and 20% among the preterms. Etilism was observed in 15% of the women in the term group and in 25% of the preterms. There was a report of use of drugs of 2.5% in both groups. The incidence of pre-eclampsia was found in 1 (1.25%) patient who belonged to the preterm group. The pregnancy-induced hypertensive disorder was present in 21 (26%) patients in the preterm group and 9 (22.5%) of the term group. The report of pregnancy loss occurred in 17.5% in both groups. Considering the gender of the newborns in the case group, 60% were female and 40% male. In the term group 65% of the newborns were female and 35% male. The intra-uterine growth restriction was observed in 27% of the newborns of the preterm group against 10% in the term group, a statistically significant difference. Among the mothers of small gestational age‘s newborns there was a higher prevalence of aCL/IgM. The newborn babies of women who were positive for the antibody antibodies were all female, small for gestational age and gestational age ranging from 31 to 32 weeks. The authors concluded that the prevalence of antiphospholipid antibodies found in this study accords to the literature‘s data, however it is suggested that further studies are developed to establish correlation between the presence of these antibodies and prematurity. |