Trabalho de Conclusão de Curso - Graduação

Prevalência do vírus JC e correlação com manifestações neurológicas em pacientes portadores do HIV-1 ou com AIDS internados no Hospital Universitário João de Barros Barreto, Belém, Pará

In the Acquired Immunodeficiency Sindrome (AIDS) occur neurological symptoms due to the infectious process by the Human Imunodeficiency virus (HIV) and caused by co-infection for other agents as well. Among these agents is JC virus (JCV), which is related to the presence of specific neurological sig...

ver descrição completa

Autor principal: LOPES, João da Cunha
Grau: Trabalho de Conclusão de Curso - Graduação
Publicado em: 2023
Assuntos:
HIV
JCV
AIDS
LMP
CNPQ::CIENCIAS DA SAUDE::MEDICINA
Acesso em linha: https://bdm.ufpa.br:8443/jspui/handle/prefix/4979
id oai:https:--bdm.ufpa.br:8443:prefix-4979
recordtype dspace
spelling oai:https:--bdm.ufpa.br:8443:prefix-49792023-01-14T03:06:51Z Prevalência do vírus JC e correlação com manifestações neurológicas em pacientes portadores do HIV-1 ou com AIDS internados no Hospital Universitário João de Barros Barreto, Belém, Pará LOPES, João da Cunha MACHADO, Luiz Fernando Almeida http://lattes.cnpq.br/8099461017092882 https://orcid.org/0000-0002-4571-4715 HIV JCV AIDS LMP CNPQ::CIENCIAS DA SAUDE::MEDICINA In the Acquired Immunodeficiency Sindrome (AIDS) occur neurological symptoms due to the infectious process by the Human Imunodeficiency virus (HIV) and caused by co-infection for other agents as well. Among these agents is JC virus (JCV), which is related to the presence of specific neurological signals and symptoms across a spectrum of neurologic states called Progressive Multifocal Leukoencephalopathy (LMP), serious, fatal demyelinating disease of the central nervous system, that usually appear immunocompromised specially in the setting of AIDS. Currently, with the use of Higly active antiretroviral therapy (HAART) the classical LMP became less comom giving place to weak and moderate symptoms of the presence of JCV x HIV co-infection. This way the JCV co-infection early diagnosys is important and can be in a very easy way with the urine examination of these patients featuring the polimerase chain reaction (PCR) to detect the viral genome presence. The present work analyse urine samples in patients with AIDS to JCV detection and then try to associate the JCV presence with the neurologic manifestations on these patients. This way it was collected urine samples from 50 HIV infected patients and analysed about the presence of JCV genome by PCR technique that have shown 20 of them (40%) coinfected by JCV. Then, all of them from the two groups, monoinfected (only HIV infection) and double infected (HIV x JCV infection) have their hospital register analysed about the prevalence of the following neurological signals and symptoms: headache, walk disability, motor discordination, balance disability, convulsion, language disability, demency, hemiplegy or hemiparesy and paresthesy. As result it was observed that the monoinfected group (only by HIV), 17 56,65%) presented some of the avaluated neurological symptoms once 13(43,35%) kept without any of it. On the other hand, in the double infected group it was observed that 13(65%) presented it, once 7(35%) kept without any neurological symptoms. That was also observed that the most frequent of these symptoms were: headache 20(40%), paresthesias 7(14%) and hemiparesia 9(18%). These results demonstrate that the development of neurological symptoms were not significantly influenced by the presence of co-infection HIV x JCV. Na Síndrome da Imunodeficiência Adquirida (AIDS) ocorrem manifestações neurológicas decorrentes do efeito da ação do próprio Vírus da imunodeficiência humana (HIV), bem como decorrentes de co-infecção por outros agentes, tais como o Vírus JC (JCV), que está relacionado com a presença de sinais e sintomas neurológicos específicos podendo levar à Leucoencefalopatia Multifocal Progressiva (LMP) que é uma síndrome desmielinizante grave e letal. O presente trabalho descreve a prevalência do JCV em uma população de indivíduos portadores do HIV internados no Hospital Universitário João de Barros Barreto e a sua correlação com as manifestações neurológicas observadas nestes pacientes. Foram coletadas amostras de urina de 50 pacientes para a detecção do JCV e as informações clínicas foram obtidas a partir dos prontuários médicos de cada indivíduo, internados no período de setembro de 2006 a dezembro de 2007. A prevalência da infecção pelo JCV na população examinada foi de 40,0% (20/50) sendo que a ocorrência de manifestações neurológicas foi mais observada no grupo de pacientes que eram portadores da co-infecção HIV/JCV (13/50; 26%), quando comparados com o grupo de portadores somente do HIV (17/50; 34%), embora a diferença não tenha se mostrado estatisticamente significativa (2=0,086; p=0,9532). As manifestações neurológicas mais freqüentemente relatadas nos dois grupos foram cefaléia (40%), parestesias (14%) e hemiparesia (18%). Desta forma, talvez em virtude do pequeno tamanho amostral, não houve correlação entre a presença da co-infecção HIV/JCV e o aumento da freqüência de manifestações neurológicas na amostra avaliada. Contudo há que se afastar outras causas de manifestações neurológicas no HIV tais como linfoma primário do SNC, Toxoplasmose e o Complexo Demencial Relacionado à AIDS que também podem cursar com a sintomatologia neurológica pesquisada neste trabalho. 2023-01-13T18:04:29Z 2023-01-13T18:04:29Z 2008 Trabalho de Conclusão de Curso - Graduação LOPES, João da Cunha. Prevalência do vírus JC e correlação com manifestações neurológicas em pacientes portadores do HIV-1 ou com AIDS internados no Hospital Universitário João de Barros Barreto, Belém, Pará. Orientador: Luiz Fernando Almeida Machado. 2008. 30 f. Trabalho de Conclusão de Curso (Bacharelado em Medicina) - Faculdade de Medicina, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2008. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/4979. Acesso em:. https://bdm.ufpa.br:8443/jspui/handle/prefix/4979 Acesso Aberto 1 CD ROM
institution Biblioteca Digital de Monografias - UFPA
collection MonografiaUFPA
topic HIV
JCV
AIDS
LMP
CNPQ::CIENCIAS DA SAUDE::MEDICINA
spellingShingle HIV
JCV
AIDS
LMP
CNPQ::CIENCIAS DA SAUDE::MEDICINA
LOPES, João da Cunha
Prevalência do vírus JC e correlação com manifestações neurológicas em pacientes portadores do HIV-1 ou com AIDS internados no Hospital Universitário João de Barros Barreto, Belém, Pará
topic_facet HIV
JCV
AIDS
LMP
CNPQ::CIENCIAS DA SAUDE::MEDICINA
description In the Acquired Immunodeficiency Sindrome (AIDS) occur neurological symptoms due to the infectious process by the Human Imunodeficiency virus (HIV) and caused by co-infection for other agents as well. Among these agents is JC virus (JCV), which is related to the presence of specific neurological signals and symptoms across a spectrum of neurologic states called Progressive Multifocal Leukoencephalopathy (LMP), serious, fatal demyelinating disease of the central nervous system, that usually appear immunocompromised specially in the setting of AIDS. Currently, with the use of Higly active antiretroviral therapy (HAART) the classical LMP became less comom giving place to weak and moderate symptoms of the presence of JCV x HIV co-infection. This way the JCV co-infection early diagnosys is important and can be in a very easy way with the urine examination of these patients featuring the polimerase chain reaction (PCR) to detect the viral genome presence. The present work analyse urine samples in patients with AIDS to JCV detection and then try to associate the JCV presence with the neurologic manifestations on these patients. This way it was collected urine samples from 50 HIV infected patients and analysed about the presence of JCV genome by PCR technique that have shown 20 of them (40%) coinfected by JCV. Then, all of them from the two groups, monoinfected (only HIV infection) and double infected (HIV x JCV infection) have their hospital register analysed about the prevalence of the following neurological signals and symptoms: headache, walk disability, motor discordination, balance disability, convulsion, language disability, demency, hemiplegy or hemiparesy and paresthesy. As result it was observed that the monoinfected group (only by HIV), 17 56,65%) presented some of the avaluated neurological symptoms once 13(43,35%) kept without any of it. On the other hand, in the double infected group it was observed that 13(65%) presented it, once 7(35%) kept without any neurological symptoms. That was also observed that the most frequent of these symptoms were: headache 20(40%), paresthesias 7(14%) and hemiparesia 9(18%). These results demonstrate that the development of neurological symptoms were not significantly influenced by the presence of co-infection HIV x JCV.
author_additional MACHADO, Luiz Fernando Almeida
author_additionalStr MACHADO, Luiz Fernando Almeida
format Trabalho de Conclusão de Curso - Graduação
author LOPES, João da Cunha
title Prevalência do vírus JC e correlação com manifestações neurológicas em pacientes portadores do HIV-1 ou com AIDS internados no Hospital Universitário João de Barros Barreto, Belém, Pará
title_short Prevalência do vírus JC e correlação com manifestações neurológicas em pacientes portadores do HIV-1 ou com AIDS internados no Hospital Universitário João de Barros Barreto, Belém, Pará
title_full Prevalência do vírus JC e correlação com manifestações neurológicas em pacientes portadores do HIV-1 ou com AIDS internados no Hospital Universitário João de Barros Barreto, Belém, Pará
title_fullStr Prevalência do vírus JC e correlação com manifestações neurológicas em pacientes portadores do HIV-1 ou com AIDS internados no Hospital Universitário João de Barros Barreto, Belém, Pará
title_full_unstemmed Prevalência do vírus JC e correlação com manifestações neurológicas em pacientes portadores do HIV-1 ou com AIDS internados no Hospital Universitário João de Barros Barreto, Belém, Pará
title_sort prevalência do vírus jc e correlação com manifestações neurológicas em pacientes portadores do hiv-1 ou com aids internados no hospital universitário joão de barros barreto, belém, pará
publishDate 2023
url https://bdm.ufpa.br:8443/jspui/handle/prefix/4979
_version_ 1787155387639660544
score 11.653393

Registros relacionados