Estudo de série de casos de pacientes com hipercolesterolemia familiar: uma abordagem clínico nutricional
Introduction: The Familial Hypercholesterolemia (FH) is a is an underdiagnosed autosomal codominant hereditary disease that lead to increased levels of low density lipoprotein (LDL-c) and has two distinct phenotypes: the homozygote, a rare form of this disease with frequency of...
| Autor principal: | RIBEIRO, Camila dos Santos |
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| Grau: | Trabalho de Conclusão de Curso - Graduação |
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2023
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https://bdm.ufpa.br:8443/jspui/handle/prefix/5181 |
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oai:https:--bdm.ufpa.br:8443:prefix-51812023-01-31T03:06:48Z Estudo de série de casos de pacientes com hipercolesterolemia familiar: uma abordagem clínico nutricional RIBEIRO, Camila dos Santos SILVA, Luiz Carlos Santana da http://lattes.cnpq.br/6161491684526382 ARAÚJO, Marília de Souza http://lattes.cnpq.br/9371703949781020 https://orcid.org/0000-0003-1017-6221 Hiperlipoproteinemia tipo II Avaliação nutricional Antropometria Hyperlipoproteinemia type II Nutrition assessment Anthropometry CNPQ::CIENCIAS DA SAUDE::NUTRICAO Introduction: The Familial Hypercholesterolemia (FH) is a is an underdiagnosed autosomal codominant hereditary disease that lead to increased levels of low density lipoprotein (LDL-c) and has two distinct phenotypes: the homozygote, a rare form of this disease with frequency of 1:1 million inhabitants; and the heterozygote which frequency is estimated to be 1:250 inhabitants. Objectives: To describe the clinical and nutritional aspects of two patients with FH. Methods: Data were collected from medical records, which were tabulated in Excel spreadsheets. Weight, height, arm circumference, waist circumference and triceps and subscapular skinfolds were measured and a simplified food frequency questionnaire was applied for anthropometric and nutritional assessment. Results: One male homozygous case (FHHo-case 1) and one female heterozygous case (FHHe-case 2) were evaluated and distinct characteristics were observed in each case. The case 1 had maximum LDL-c levels, with 760 mg / dL, but responded to therapy with significant LDL-c levels decrease, and presents tuberous xanthomas and corneal arches. He was diagnosed with malnutrition, his growth curve showed thinness in the parameter BMI/age and adequate intake of food markers for cardiovascular risk was recorded. The case 2 presented a maximum level of LDL-c 256 mg/dL, firstly diagnosed with central precocious puberty, eutrophy according to anthropometry and excessive intake of food markers for cardiovascular risk. Conclusion: For the evaluated patients, the diet does not seem to be sufficient to contain LDL-c levels, however must be paid attention to the dietary management of these patients. In addition more clinical- nutritional studies are needed on this disease. Introdução: A hipercolesterolemia familiar (HF) é uma doença hereditária autossômica codominante, subdiagnosticada, que causa níveis elevados da lipoproteína de baixa densidade (LDLc) e possui dois fenótipos distintos: homozigoto, que é uma forma rara por afetar 1:1 milhão de pessoas; e heterozigoto, com frequência estimada em 1:250 pessoas. Objetivos: Descrever os aspectos clínicos e nutricionais de dois pacientes com HF. Métodos: Foram coletados dados dos prontuários, que foram tabulados em planilhas de Excel. Foi aferido peso, estatura, circunferência do braço, circunferência da cintura e pregas cutâneas tricipital e subescapular e aplicado um questionário de frequência alimentar simplificado para a avaliação antropométrica e nutricional. Resultados: Foi avaliado um caso homozigótico (HFHo) do sexo masculino (caso 1), e outro heterozigótico (HFHe) do sexo feminino (caso 2), no qual foram observadas características distintas. O caso 1 teve níveis de LDL-c máximo de 760 mg/dL, mas respondeu à terapia com decréscimo significativo, apresenta xantomas tuberosos e arcos cornealis. Foi diagnosticado com desnutrição, sua curva de crescimento mostrou magreza no parâmetro IMC/I e registrado consumo adequado de alimentos marcadores de risco cardiovascular. O caso 2 teve nível máximo de LDL-c 256 mg/dL, diagnosticada primeiramente com puberdade precoce central, eutrofia segundo antropometria e consumo excessivo de alimentos marcadores de risco cardiovascular. Conclusão: Para os pacientes avaliados, a dieta parece não ser suficiente para conter os níveis de LDL-c, mas deve-se ter atenção no manejo dietético desses pacientes. Ademais mais estudos clínicos-nutricionais são necessários sobre essa doença. 2023-01-30T18:11:04Z 2023-01-30T18:11:04Z 2019 Trabalho de Conclusão de Curso - Graduação RIBEIRO, Camila dos Santos. Estudo de série de casos de pacientes com hipercolesterolemia familiar: uma abordagem clínico nutricional. Orientador: Luiz Carlos Santana da Silva. 2019. 54 f. Trabalho de Conclusão de Curso (Bacharelado em Nutrição) - Faculdade de Nutrição, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2019. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/5181. Acesso em:. https://bdm.ufpa.br:8443/jspui/handle/prefix/5181 Acesso Aberto Disponível na Internet via correio eletrônico: bibsaude@ufpa.br |
| institution |
Biblioteca Digital de Monografias - UFPA |
| collection |
MonografiaUFPA |
| topic |
Hiperlipoproteinemia tipo II Avaliação nutricional Antropometria Hyperlipoproteinemia type II Nutrition assessment Anthropometry CNPQ::CIENCIAS DA SAUDE::NUTRICAO |
| spellingShingle |
Hiperlipoproteinemia tipo II Avaliação nutricional Antropometria Hyperlipoproteinemia type II Nutrition assessment Anthropometry CNPQ::CIENCIAS DA SAUDE::NUTRICAO RIBEIRO, Camila dos Santos Estudo de série de casos de pacientes com hipercolesterolemia familiar: uma abordagem clínico nutricional |
| topic_facet |
Hiperlipoproteinemia tipo II Avaliação nutricional Antropometria Hyperlipoproteinemia type II Nutrition assessment Anthropometry CNPQ::CIENCIAS DA SAUDE::NUTRICAO |
| description |
Introduction: The Familial Hypercholesterolemia (FH) is a is an underdiagnosed
autosomal codominant hereditary disease that lead to increased levels of low density
lipoprotein (LDL-c) and has two distinct phenotypes: the homozygote, a rare form of
this disease with frequency of 1:1 million inhabitants; and the heterozygote which
frequency is estimated to be 1:250 inhabitants. Objectives: To describe the clinical
and nutritional aspects of two patients with FH. Methods: Data were collected from
medical records, which were tabulated in Excel spreadsheets. Weight, height, arm
circumference, waist circumference and triceps and subscapular skinfolds were
measured and a simplified food frequency questionnaire was applied for
anthropometric and nutritional assessment. Results: One male homozygous case
(FHHo-case 1) and one female heterozygous case (FHHe-case 2) were evaluated
and distinct characteristics were observed in each case. The case 1 had maximum
LDL-c levels, with 760 mg / dL, but responded to therapy with significant LDL-c levels
decrease, and presents tuberous xanthomas and corneal arches. He was diagnosed
with malnutrition, his growth curve showed thinness in the parameter BMI/age and
adequate intake of food markers for cardiovascular risk was recorded. The case 2
presented a maximum level of LDL-c 256 mg/dL, firstly diagnosed with central
precocious puberty, eutrophy according to anthropometry and excessive intake of
food markers for cardiovascular risk. Conclusion: For the evaluated patients, the diet
does not seem to be sufficient to contain LDL-c levels, however must be paid
attention to the dietary management of these patients. In addition more clinical- nutritional studies are needed on this disease. |
| author_additional |
SILVA, Luiz Carlos Santana da |
| author_additionalStr |
SILVA, Luiz Carlos Santana da |
| format |
Trabalho de Conclusão de Curso - Graduação |
| author |
RIBEIRO, Camila dos Santos |
| title |
Estudo de série de casos de pacientes com hipercolesterolemia familiar: uma abordagem clínico nutricional |
| title_short |
Estudo de série de casos de pacientes com hipercolesterolemia familiar: uma abordagem clínico nutricional |
| title_full |
Estudo de série de casos de pacientes com hipercolesterolemia familiar: uma abordagem clínico nutricional |
| title_fullStr |
Estudo de série de casos de pacientes com hipercolesterolemia familiar: uma abordagem clínico nutricional |
| title_full_unstemmed |
Estudo de série de casos de pacientes com hipercolesterolemia familiar: uma abordagem clínico nutricional |
| title_sort |
estudo de série de casos de pacientes com hipercolesterolemia familiar: uma abordagem clínico nutricional |
| publishDate |
2023 |
| url |
https://bdm.ufpa.br:8443/jspui/handle/prefix/5181 |
| _version_ |
1787155425805729792 |
| score |
11.753896 |