INTRODUCTION: Breast carcinoma is the main cause of cancer-related mortality in women
worldwide and Brazil has high incidence and prevalence rates. OBJECTIVES: To investigate
the clinical-epidemiological profile of patients, such as histopathological characteristics,
molecular classification based on immunohistochemistry of breast carcinoma and response to
treatment. METHODOLOGY: 320 patients had detailed medical records and, of these, 263
histopathological and immunohistochemical reports were prepared from patients treated at
HUJBB from 2018 to 2022. Subsequently, the information was entered into a secure platform,
REDCap (Research Electronic Data Capture ), to carry out statistical analyzes and prepare
reports and tables. Data analysis explored the following variables: age, histological types,
molecular classification, neoadjuvant treatment and pathological response. RESULTS: All
patients were female with a mean age of 54 years. There were 220 cases of invasive carcinoma
of the non-special type and 11 of invasive lobular carcinoma, the most common. Regarding
molecular classification, 29.6% were Luminal B-like; 28.6% triple negative; 24.5% Luminal A
type; 9.9% HER-2 positive and 7.5% Luminal B with HER-2 positive. The death rate was
16.9%. In 52 of the 98 patients undergoing neoadjuvant therapy, the pathological response was
proven. A complete response was observed in 26.9%; 63.5% had an incomplete response and
9.6% had no therapeutic response. Of the 52 patients, there was no association with pathological
response, number of deaths, molecular classification and histological type. CONCLUSION:
Invasive carcinoma of the non-special type was the most frequent histological type, as well as
the Luminal B-like and triple negative molecular profiles. Patients with a complete response
had no recorded deaths. A detailed analysis of all these aspects contributes to the understanding
of the disease and helps to promote improvements in diagnosis and treatment strategies.
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