Introduction: Hypertension (HTN) is a global public health concern, affecting approximately
1.28 billion adults worldwide. In addition to the serious complications of HTN, the challenge
of Resistant Hypertension (RH) arises—a condition characterized by the inability to control
blood pressure despite treatment with multiple medications. This study analyzed the profile of
patients with RH at the João de Barros Barreto University Hospital (HUJBB), investigating
comorbidities, treatment adherence, and intervention effectiveness. Objective: To analyze the
profile of patients with RH at HUJBB, investigating their relationship with sex, age, most
prescribed medications, treatment adherence, therapeutic efficacy, and comorbidities.
Methodology: The study was cross-sectional, descriptive, and analytical, with the analysis of
238 medical records selected based on inclusion criteria, which included patients aged
between 18 and 75 years, with RH, and treated between January 2020 and December 2021.
Data on sex, age, treatment adherence, comorbidities, prescribed medications, and blood
pressure levels before and after treatment were reviewed. The G-test and T-test of correlation
were applied for statistical analysis. Results: The profile of analyzed patients with RH reveals
a predominance of females, advanced age, the presence of dyslipidemia, and obesity.
Treatment adherence had a significant impact on the classification of hypertension, with the
majority of adherent patients now falling into less severe stages of the condition. The most
common medication combinations included angiotensin receptor blockers, calcium channel
blockers, and thiazide diuretics. Dyslipidemia and obesity were correlated with blood pressure
levels before treatment, while diabetes and treatment adherence showed an association with
blood pressure levels after treatment. Conclusion: The study unveiled a characteristic profile
of patients with RH at HUJBB and emphasized the importance of treatment adherence and the
appropriate choice of medications. These findings provide valuable insights for improving RH
management and the development of effective prevention and treatment strategies.
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