Insulin resistance is a term that refers to the ineffective action of insulin in tissues,
being developed by several factors, from infectious and nutritional diseases to
the hormonal influence by endocrinopathies, use of diabetogenic drugs and
physiological hormonal periods in female dogs. This review aims to describe the
influence of female sex steroid hormones on the triggering of insulin resistance
in non-castrated female dogs. It is observed that the mechanism of action of
insulin is compromised by the action of progesterone and estradiol in the body in
addition to other hyperglycemic hormones that together with genetic,
environmental and autoimmune factors, can trigger transient or gestational
diabetes in female dogs. It is concluded that diabetes mellitus in whole canine
patients intensifies the definition of endocrinopathy as a multifactorial disorder,
where there are few studies involving transient or gestational diabetes mellitus,
but its risk is mentioned in the literature due to the possibility of a permanent
picture in some cases. and for being responsible for conveying the importance of
castration in the control of diabetic bitches and in the prevention of those at risk.
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