Introduction: COVID-19 is an infectious disease caused by SARS-COV-2, which is characterized by a high degree of contagion and a wide range of clinical manifestations that can be mild, moderate and intense, affecting different organs and systems, including these the nervous system, due to its characteristics of neurotropism. Recently, the existence of long-term effects in already infected individuals has been confirmed, however these effects are not fully understood, ranging from headaches or body aches to limitations in functionality. Methods: Prospective cross-sectional observational study, which investigated the presence of neuropsychiatric symptoms and level of functionality in adult individuals already affected by COVID-19, through the application of a PRO questionnaire and functionality scale on an online platform. Results: 62 adult individuals of both sexes, already infected with SARS-COV-2 participated in this study, mostly young women, the incidence percentages of the most reported symptoms were headache 37.7%, anxiety 41.9% and confusion /lack of concentration 29.0%, 46.8% of the participants have severe functionality limitations, in the crossing of the proportion of symptoms and vaccine doses taken, there was no relationship of the number of doses for all symptoms, but for the relationship of impairment of functionality and presence or absence of symptoms for anxiety (p<0.001), for depression (p=0.009), for confusion/lack of concentration (p=0.008) and dizziness (p=0.049). Conclusion: The most frequently reported symptoms were headache, anxiety and confusion / lack of concentration, almost half of the participants had severe functionality limitations and there is a statistically significant difference when relating the level of functionality impairment with the symptoms of anxiety, depression, confusion/high concentration and dizziness in addition, the number of vaccine doses does not interfere with the presence or absence of symptoms in these patients.
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