Nanotecnologia na terapia de doenças neurodegenerativas: Alzheimer e Parkinson
Neurodegenerative diseases, such as Alzheimer's and Parkinson's, have represented a growing challenge to global public health. The increase in life expectancy emphasizes the urgency for innovative and effective therapeutic approaches. Nanotechnology emerges as a promising area leading this fight, of...
| Autor principal: | Castro, Juliane Souza de |
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| Grau: | Trabalho de Conclusão de Curso |
| Idioma: | por |
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Brasil
2024
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oai:localhost:prefix-74992025-03-10T21:17:46Z Nanotecnologia na terapia de doenças neurodegenerativas: Alzheimer e Parkinson Castro, Juliane Souza de Kaufmann, Giana Thais http://lattes.cnpq.br/6176113716808731 Ghizoni, Cristiane Vizioli de Castro Costa, Flávio Nogueira da Nanotecnologia Doenças neurodegenerativas Doença de Alzheimer Doença de Parkinson Nanotechnology Neurodegenerative diseases Alzheimer's disease Parkinson's disease CIENCIAS DA SAUDE . . . Neurodegenerative diseases, such as Alzheimer's and Parkinson's, have represented a growing challenge to global public health. The increase in life expectancy emphasizes the urgency for innovative and effective therapeutic approaches. Nanotechnology emerges as a promising area leading this fight, offering potentially revolutionary solutions. Traditional therapies face significant difficulties, such as the inability to cross the blood-brain barrier (BBB) and the lack of specificity in targeting therapies to affected sites in the brain, resulting in reduced efficacy and adverse side effects. This work aims to evaluate, through an integrative review, the potential and effectiveness of nanotechnologies applied in therapies for Alzheimer's and Parkinson's diseases. Studies highlight that nanoparticles, such as liposomes, dendrimers and polymeric nanoparticles, offer significant advances in drug delivery to the brain, improving bioavailability and therapeutic efficacy. Functionalized liposomes and poly-lactic-co-glycolic acid (PLGA) nanoparticles have shown promise in sustained drug release and crossing the BBB. Nanotechnology has the potential to transform the treatment of neurodegenerative diseases, offering new possibilities for precise drug delivery and overcoming limitations of traditional therapies. The findings highlight the importance of nanotechnology in evolving therapeutic approaches for Alzheimer's disease and Parkinson's disease, paving the way for more effective and less invasive treatments. As doenças neurodegenerativas, como Alzheimer e Parkinson, têm representado um desafio crescente para a saúde pública global. O aumento da expectativa de vida acentua a urgência por abordagens terapêuticas inovadoras e eficazes. A nanotecnologia emerge como uma área promissora na liderança dessa luta, oferecendo soluções potencialmente revolucionárias. As terapias tradicionais enfrentam dificuldades significativas, como a incapacidade de atravessar a barreira hematoencefálica (BHE) e a falta de especificidade no direcionamento das terapias aos locais afetados no cérebro, resultando em eficácia reduzida e efeitos colaterais adversos. Este trabalho visa avaliar, por meio de revisão integrativa, o potencial e a eficácia das nanotecnologias aplicadas em terapias para as doenças de Alzheimer e Parkinson. Estudos destacam que nanopartículas, como lipossomas, dendrímeros e nanopartículas poliméricas, oferecem avanços significativos na entrega de medicamentos ao cérebro, melhorando a biodisponibilidade e a eficácia terapêutica. Lipossomas funcionalizados e nanopartículas de ácido poli-lático-co-glicólico (PLGA) mostraram-se promissores na liberação sustentada de medicamentos e na travessia da BHE. A nanotecnologia tem o potencial de transformar o tratamento de doenças neurodegenerativas, oferecendo novas possibilidades para a entrega precisa de medicamentos e superando limitações das terapias tradicionais. As descobertas ressaltam a importância da nanotecnologia na evolução das abordagens terapêuticas para a doença de Alzheimer e doença de Parkinson, abrindo caminho para tratamentos mais eficazes e menos invasivos. 3 Não 2024-08-07T21:45:49Z 2024-08-07T21:45:49Z 2024-07-29 Trabalho de Conclusão de Curso http://riu.ufam.edu.br/handle/prefix/7499 por Acesso Aberto https://creativecommons.org/licenses/by-nc-nd/4.0/ Brasil ICET - Instituto de Ciências Exatas e Tecnologia (Itacoatiara) Itacoatiara (AM) Farmácia - Bacharelado - Itacoatiara |
| institution |
Repositório Institucional - Universidade Federal do Amazonas |
| collection |
RI-UFAM |
| language |
por |
| topic |
Nanotecnologia Doenças neurodegenerativas Doença de Alzheimer Doença de Parkinson Nanotechnology Neurodegenerative diseases Alzheimer's disease Parkinson's disease CIENCIAS DA SAUDE . . . |
| spellingShingle |
Nanotecnologia Doenças neurodegenerativas Doença de Alzheimer Doença de Parkinson Nanotechnology Neurodegenerative diseases Alzheimer's disease Parkinson's disease CIENCIAS DA SAUDE . . . Castro, Juliane Souza de Nanotecnologia na terapia de doenças neurodegenerativas: Alzheimer e Parkinson |
| topic_facet |
Nanotecnologia Doenças neurodegenerativas Doença de Alzheimer Doença de Parkinson Nanotechnology Neurodegenerative diseases Alzheimer's disease Parkinson's disease CIENCIAS DA SAUDE . . . |
| description |
Neurodegenerative diseases, such as Alzheimer's and Parkinson's, have represented a growing challenge to global public health. The increase in life expectancy emphasizes the urgency for innovative and effective therapeutic approaches. Nanotechnology emerges as a promising area leading this fight, offering potentially revolutionary solutions. Traditional therapies face significant difficulties, such as the inability to cross the blood-brain barrier (BBB) and the lack of specificity in targeting therapies to affected sites in the brain, resulting in reduced efficacy and adverse side effects. This work aims to evaluate, through an integrative review, the potential and effectiveness of nanotechnologies applied in therapies for Alzheimer's and Parkinson's diseases. Studies highlight that nanoparticles, such as liposomes, dendrimers and polymeric nanoparticles, offer significant advances in drug delivery to the brain, improving bioavailability and therapeutic efficacy. Functionalized liposomes and poly-lactic-co-glycolic acid (PLGA) nanoparticles have shown promise in sustained drug release and crossing the BBB. Nanotechnology has the potential to transform the treatment of neurodegenerative diseases, offering new possibilities for precise drug delivery and overcoming limitations of traditional therapies. The findings highlight the importance of nanotechnology in evolving therapeutic approaches for Alzheimer's disease and Parkinson's disease, paving the way for more effective and less invasive treatments. |
| author_additional |
Kaufmann, Giana Thais |
| author_additionalStr |
Kaufmann, Giana Thais |
| format |
Trabalho de Conclusão de Curso |
| author |
Castro, Juliane Souza de |
| title |
Nanotecnologia na terapia de doenças neurodegenerativas: Alzheimer e Parkinson |
| title_short |
Nanotecnologia na terapia de doenças neurodegenerativas: Alzheimer e Parkinson |
| title_full |
Nanotecnologia na terapia de doenças neurodegenerativas: Alzheimer e Parkinson |
| title_fullStr |
Nanotecnologia na terapia de doenças neurodegenerativas: Alzheimer e Parkinson |
| title_full_unstemmed |
Nanotecnologia na terapia de doenças neurodegenerativas: Alzheimer e Parkinson |
| title_sort |
nanotecnologia na terapia de doenças neurodegenerativas: alzheimer e parkinson |
| publisher |
Brasil |
| publishDate |
2024 |
| url |
http://riu.ufam.edu.br/handle/prefix/7499 |
| _version_ |
1831970120970272768 |
| score |
11.753896 |