Artigo

Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine

Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations co...

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Autor principal: Comandolli-Wyrepkowski, Claudia Dantas
Outros Autores: Grafova, Iryna, Naiff, Maricleide de Farias, Avella, Maurizio, Gentile, Gennaro, Grafov, Andrèi Andriy, Franco, A. M.
Grau: Artigo
Idioma: English
Publicado em: Acta Amazonica 2020
Acesso em linha: https://repositorio.inpa.gov.br/handle/1/14049
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spelling oai:repositorio:1-14049 Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine Tratamento tópico da leishmaniose cutânea experimental em golden hamsters (Mesocricetus auratus) com fórmulas contendo pentamidina Comandolli-Wyrepkowski, Claudia Dantas Grafova, Iryna Naiff, Maricleide de Farias Avella, Maurizio Gentile, Gennaro Grafov, Andrèi Andriy Franco, A. M. Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamsters (Mesocricetus auratus) were infected in the nose with Leishmania (Leishmania) amazonensis. Six treatment groups received different topical treatments of anhydrous or hydrating emulsions, for a maximum of 10 days, with an application of 50 mg day-1. After treatment tissue samples of lesions were evaluated by histology, transmission electron microscopy and biopsy cultivation. Compared with untreated group, topical treatment with hydrating emulsion with 10% PI and usnic acid (ACE5AU) showed significantly decrease in volume lesion (P= 0.028) on 20th day after the end of the treatment with reduction of 27.37%. Topical treatment with anhydrous emulsion with 10% PI and usnic acid (ACPU) reduces parasite burden in Golden hamsters. This study demonstrated the potential of topical treatment to reduce the number of parasites that could be combined with others drugs and to have a faster and more effective treatment of cutaneous leishmaniasis. © 2017, Instituto Nacional de Pesquisas da Amazonia. All right reserved. 2020-04-24T16:27:46Z 2020-04-24T16:27:46Z 2017 Artigo https://repositorio.inpa.gov.br/handle/1/14049 10.1590/1809-4392201601333 en Volume 47, Número 1, Pags. 39-46 Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Acta Amazonica
institution Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional
collection INPA-RI
language English
description Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamsters (Mesocricetus auratus) were infected in the nose with Leishmania (Leishmania) amazonensis. Six treatment groups received different topical treatments of anhydrous or hydrating emulsions, for a maximum of 10 days, with an application of 50 mg day-1. After treatment tissue samples of lesions were evaluated by histology, transmission electron microscopy and biopsy cultivation. Compared with untreated group, topical treatment with hydrating emulsion with 10% PI and usnic acid (ACE5AU) showed significantly decrease in volume lesion (P= 0.028) on 20th day after the end of the treatment with reduction of 27.37%. Topical treatment with anhydrous emulsion with 10% PI and usnic acid (ACPU) reduces parasite burden in Golden hamsters. This study demonstrated the potential of topical treatment to reduce the number of parasites that could be combined with others drugs and to have a faster and more effective treatment of cutaneous leishmaniasis. © 2017, Instituto Nacional de Pesquisas da Amazonia. All right reserved.
format Artigo
author Comandolli-Wyrepkowski, Claudia Dantas
spellingShingle Comandolli-Wyrepkowski, Claudia Dantas
Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine
author2 Grafova, Iryna
Naiff, Maricleide de Farias
Avella, Maurizio
Gentile, Gennaro
Grafov, Andrèi Andriy
Franco, A. M.
author2Str Grafova, Iryna
Naiff, Maricleide de Farias
Avella, Maurizio
Gentile, Gennaro
Grafov, Andrèi Andriy
Franco, A. M.
title Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine
title_short Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine
title_full Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine
title_fullStr Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine
title_full_unstemmed Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine
title_sort topical treatment of experimental cutaneous leishmaniasis in golden hamster (mesocricetus auratus) with formulations containing pentamidine
publisher Acta Amazonica
publishDate 2020
url https://repositorio.inpa.gov.br/handle/1/14049
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score 11.755432

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