Structure and antinociceptive effects of β-d-glucans from Cookeina tricholoma
Structurally different water-insoluble (1 → 3),(1 → 6) β-d-glucans were isolated from aqueous and alkaline extracts of the mushroom-forming ascomycete Cookeina tricholoma, a wild edible mushroom found in Brazilian Amazon forest. The structures showed different substitution patterns, which may influe...
| Autor principal: | Moreno, Roberta Barbara |
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| Outros Autores: | Ruthes, Andrea Caroline, Baggio, C. H., Vilaplana, Francisco, Komura, Dirce Leimi, Iacomini, Marcello |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
Carbohydrate Polymers
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/17332 |
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oai:repositorio:1-17332 |
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oai:repositorio:1-17332 Structure and antinociceptive effects of β-d-glucans from Cookeina tricholoma Moreno, Roberta Barbara Ruthes, Andrea Caroline Baggio, C. H. Vilaplana, Francisco Komura, Dirce Leimi Iacomini, Marcello Chains Fungi Antinociceptive Effect Ascomycete Brazilian Amazon Cookeina Tricholoma Extractability Glucans Substitution Patterns Wild Edible Mushrooms Polysaccharides Analgesic Agent Fungal Polysaccharide Glucan Animals Ascomycetes Chemistry Drug Effects Female Mouse Nociception Analgesics Animal Ascomycota Female Fungal Polysaccharides Glucans Mice Nociception Structurally different water-insoluble (1 → 3),(1 → 6) β-d-glucans were isolated from aqueous and alkaline extracts of the mushroom-forming ascomycete Cookeina tricholoma, a wild edible mushroom found in Brazilian Amazon forest. The structures showed different substitution patterns, which may influence their extractability and consequently their conformation in solution, and different MW (4.3 × 105 Da, 3.7 × 105 Da and 8.2 × 105 Da, for ICW-Ct, IHW-Ct and IK2-Ct, respectively). The main-chains are composed of (1 → 3)-linked β-d-Glcp units O-6 substituted by side chains with different lengths of (1 → 6)-linked β-d-Glcp units (ICW-Ct and IHW-Ct) or by a combination of (1 → 6)-linked β-d-Glcp units and single units of β-d-Glcp (IK2-Ct). β-d-glucans with similar MW and showing only (1 → 6)-linked β-d-Glcp units as side chains (ICW-Ct and IHW-Ct) showed significant inhibition of neurogenic pain, 69 ± 11 and 57 ± 11% at the dose of 10 mg kg-1, respectively, in the model of nociception induced by intraplantar injection of formalin. © 2016 Published by Elsevier Ltd. 2020-06-15T21:41:22Z 2020-06-15T21:41:22Z 2016 Artigo https://repositorio.inpa.gov.br/handle/1/17332 10.1016/j.carbpol.2016.01.001 en Volume 141, Pags. 220-228 Restrito Carbohydrate Polymers |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Chains Fungi Antinociceptive Effect Ascomycete Brazilian Amazon Cookeina Tricholoma Extractability Glucans Substitution Patterns Wild Edible Mushrooms Polysaccharides Analgesic Agent Fungal Polysaccharide Glucan Animals Ascomycetes Chemistry Drug Effects Female Mouse Nociception Analgesics Animal Ascomycota Female Fungal Polysaccharides Glucans Mice Nociception |
| spellingShingle |
Chains Fungi Antinociceptive Effect Ascomycete Brazilian Amazon Cookeina Tricholoma Extractability Glucans Substitution Patterns Wild Edible Mushrooms Polysaccharides Analgesic Agent Fungal Polysaccharide Glucan Animals Ascomycetes Chemistry Drug Effects Female Mouse Nociception Analgesics Animal Ascomycota Female Fungal Polysaccharides Glucans Mice Nociception Moreno, Roberta Barbara Structure and antinociceptive effects of β-d-glucans from Cookeina tricholoma |
| topic_facet |
Chains Fungi Antinociceptive Effect Ascomycete Brazilian Amazon Cookeina Tricholoma Extractability Glucans Substitution Patterns Wild Edible Mushrooms Polysaccharides Analgesic Agent Fungal Polysaccharide Glucan Animals Ascomycetes Chemistry Drug Effects Female Mouse Nociception Analgesics Animal Ascomycota Female Fungal Polysaccharides Glucans Mice Nociception |
| description |
Structurally different water-insoluble (1 → 3),(1 → 6) β-d-glucans were isolated from aqueous and alkaline extracts of the mushroom-forming ascomycete Cookeina tricholoma, a wild edible mushroom found in Brazilian Amazon forest. The structures showed different substitution patterns, which may influence their extractability and consequently their conformation in solution, and different MW (4.3 × 105 Da, 3.7 × 105 Da and 8.2 × 105 Da, for ICW-Ct, IHW-Ct and IK2-Ct, respectively). The main-chains are composed of (1 → 3)-linked β-d-Glcp units O-6 substituted by side chains with different lengths of (1 → 6)-linked β-d-Glcp units (ICW-Ct and IHW-Ct) or by a combination of (1 → 6)-linked β-d-Glcp units and single units of β-d-Glcp (IK2-Ct). β-d-glucans with similar MW and showing only (1 → 6)-linked β-d-Glcp units as side chains (ICW-Ct and IHW-Ct) showed significant inhibition of neurogenic pain, 69 ± 11 and 57 ± 11% at the dose of 10 mg kg-1, respectively, in the model of nociception induced by intraplantar injection of formalin. © 2016 Published by Elsevier Ltd. |
| format |
Artigo |
| author |
Moreno, Roberta Barbara |
| author2 |
Ruthes, Andrea Caroline Baggio, C. H. Vilaplana, Francisco Komura, Dirce Leimi Iacomini, Marcello |
| author2Str |
Ruthes, Andrea Caroline Baggio, C. H. Vilaplana, Francisco Komura, Dirce Leimi Iacomini, Marcello |
| title |
Structure and antinociceptive effects of β-d-glucans from Cookeina tricholoma |
| title_short |
Structure and antinociceptive effects of β-d-glucans from Cookeina tricholoma |
| title_full |
Structure and antinociceptive effects of β-d-glucans from Cookeina tricholoma |
| title_fullStr |
Structure and antinociceptive effects of β-d-glucans from Cookeina tricholoma |
| title_full_unstemmed |
Structure and antinociceptive effects of β-d-glucans from Cookeina tricholoma |
| title_sort |
structure and antinociceptive effects of β-d-glucans from cookeina tricholoma |
| publisher |
Carbohydrate Polymers |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/17332 |
| _version_ |
1787141929093300224 |
| score |
11.755432 |