Artigo

Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives

Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0μm≤IC 50≤5.0μm) against blood forms of the human malaria p...

ver descrição completa

Autor principal: Franco, Lucas Lopardi
Outros Autores: Almeida, Mauro Vieira D. de, Silva, Luiz Francisco Rocha e, Vieira, Pedro Paulo Ribeiro, Pohlit, Adrian Martin, Valle, Marcelo Siqueira
Grau: Artigo
Idioma: English
Publicado em: Chemical Biology and Drug Design 2020
Assuntos:
1,1' Peroxybis(4 Tert Butyl(hydroperoxy)cyclohexane
1,5 Bis(3,4,5 Trimethoxyphenyl)pentan 3 One
1,5 Bis(4 Methoxyphenyl)pentan 3 One
1,5 Bis(phenyl)penta 1,4 Dien 3 One
1,5 Bis(phenyl)pentan 3 One
3,3 Dihydroperoxy 1,5 (bisphenyl)pentane
3,3 Dihydroperoxy 1,5 Bis(4' Methoxyphenyl)pentane
3,3 Diphenethyl 1,2,4,5 Tetraoxaspiro[5.5]undecane
3,3,6,6 Tetraphenethyl 1,2,4,5 Tetraoxane
4 Tert Butyl 1,1 Dihydroperoxycyclohexane
Tetrabenzene
Acetone
Antimalarial Agent
Bis(arylmethyl)acetone
Dihydroperoxide
Hydroperoxide Derivative
Tetraoxane Derivative
Unclassified Drug
Antimalarial Activity
Controlled Study
Drug Synthesis
Human
In Vitro Study
Nonhuman
Plasmodium Falciparum
Priority Journal
Acetone
Antimalarials
Humans
Inhibitory Concentration 50
Malaria, Falciparum
Peroxides
Plasmodium Falciparum
Structure-activity Relationship
Tetraoxanes
Plasmodium Falciparum
Acesso em linha: https://repositorio.inpa.gov.br/handle/1/18053
Resumo:
Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0μm≤IC 50≤5.0μm) against blood forms of the human malaria parasite Plasmodium falciparum. © 2012 John Wiley & Sons A/S.

Registros relacionados