Urinary tract infection (ITU) is a frequent disease in the medical clinic. They are usually
bacterial infections and prevalent as hospitalized patients like as community patients. Currently
is known that agents causing urinary infection developed resistance to commonly used
antimicrobials, therefore, the indiscriminate use favors the increase in the number of resistant
strains. This Project aimed to establish the etiological profile and antimicrobials isolated in
urocultures of outpatients susceptibility in a historical documentary descriptive, longitudinal
retrospective study conduced at Sabin laboratory units in 11 Brazilian cities. Isolates data werw
collected between January and December 2017 in tha laboratoy system. A total of 51,386 urine
culture isolates analyzed by the study were identified, where the prevalence was women, the
most predominant age was 18 to 49 years old. About the results of the predominant
microorganisms in urinary tract infections (UTI) among the isolated microorganisms, the
majority are enterobacteria (86%) with a predominance of E. coli (69,3%), folllowed by K.
pneumoniae (8,3%). Gram Positive cocci (11,7%) were the second most isolated class, and other
classes such as non-fermenting gram-negative bacilli (NF-GNB) and fungi were the least
prevalent. About antimicrobials, E. coli showed susceptibility to meropenem (99,9%) and
ertapenem (99.9%) followed by amikacin (98.1%), nitrofurantoin (96,2%) and cefepime
(95,7%). However, the efficacy of some antimicrobials was lower, including ciprofloxacin
(72,8%), but especially norfloxacin (64,2%), sulfamethoxazole / trimetroprim (66,0%) and
nalidixic acid (65,2%). K. Pneumoniae were highly susceptible to amikacin, ertapenem and
meropenem, but are notoriously resistant to beta-lactams. When we evaluated the sensitivity of
E. coli to the four most used antimicrobials in the medical clinic, in the different regions it is
observed that it is not the same for all studied locations, being less susceptible to antimicrobials
in strains isolated in the cities of Manaus (AM), Belém (PA) and Palmas (TO). With the results
obtained in this study regarding the etiological and antimicrobial susceptibility profile of urine
cultures, the medical team has an analysis of relevant population data to support therapy, which
may improve the rational use of antibiotics.
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