This study focuses on the physicochemical characterization of the pulverized roots of Entada polyphylla Benth, commonly known as gipioca, aiming at its application in the development of a bioecological soap product, the “vegetable soap.” This Amazonian species is rich in saponins, compounds with bioactive properties including antioxidant, surfactant, and emulsifying actions, as well as cytotoxic potential. Samples were collected from three locations in the municipality of Acará, Pará, identified at the Embrapa herbarium (NID 51/2023), and subjected to physicochemical and biological analyses. Results revealed 75.92% antioxidant compounds, 17.26% total saponins, 20.32% moisture, and 12.28% tannins, highlighting the plant's potential as a source of amphiphilic and bioactive compounds. Saponin extraction was performed via sustainable water maceration, avoiding the use of harmful chemical solvents. Laboratory tests demonstrated that the pulverized material generates significant foam upon contact with water, confirming its surfactant properties and suitability for cleaning applications. The developed product was patented (BR 102024016942 5) and presented at scientific events, such as the SBPC, where it was recognized for its innovation and alignment with circular economy principles. The study also assessed the biological activity of saponins through cytotoxicity assays on tumor cell lines (AGP01, A-549, SK-MEL 19) and a non-neoplastic cell line (MRC5). Results indicated selective cytotoxicity against tumor cells, emphasizing the therapeutic potential of the extract. In addition to promoting sustainable technological solutions, the study contributes to the valorization of regional biodiversity and offers socioeconomic benefits to riverside communities, including job creation and income generation through sustainable resource management. This research expands the understanding of Amazonian legumes’ chemistry, particularly the bioactive properties of saponins, and underscores their potential as substitutes for synthetic surfactants in industries such as cosmetics, therapeutic products, and cleaning agents. It is concluded that Entada polyphylla is a promising source of natural bioactives, with technological applications that integrate innovation, socioeconomic development, and environmental preservation.
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