In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

Azevedo, Raimunda do Socorro da Silva; Sousa, Jorge R. de; Ara?jo, Marialva Tereza Ferreira de; Martins Filho, Arnaldo J; Alcantara, Bianca Nascimento de; Araujo, Fernanda M. C; Queiroz, Maria G. L.; Cruz, Ana Cec?lia Ribeiro; Vasconcelos, Beatriz H Baldez; Chiang, Jannifer Oliveira; Martins, L?via Caricio; Casseb, Livia Medeiros Neves; Silva, Eliana Vieira Pinto da; Carvalho, Val?ria Lima; Vasconcelos, Barbara C. Baldez; Rodrigues, Sueli Guerreiro; Oliveira, Consuelo Silva de; Quaresma, Juarez A. S; Vasconcelos, Pedro Fernando da Costa

Artigo

In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been proposed as ZIKV congenital syndrome. This study aimed to investigate the in situ...

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Autor principal:	Azevedo, Raimunda do Socorro da Silva
Outros Autores:	Sousa, Jorge R. de, Ara?jo, Marialva Tereza Ferreira de, Martins Filho, Arnaldo J, Alcantara, Bianca Nascimento de, Araujo, Fernanda M. C, Queiroz, Maria G. L., Cruz, Ana Cec?lia Ribeiro, Vasconcelos, Beatriz H Baldez, Chiang, Jannifer Oliveira, Martins, L?via Caricio, Casseb, Livia Medeiros Neves, Silva, Eliana Vieira Pinto da, Carvalho, Val?ria Lima, Vasconcelos, Barbara C. Baldez, Rodrigues, Sueli Guerreiro, Oliveira, Consuelo Silva de, Quaresma, Juarez A. S, Vasconcelos, Pedro Fernando da Costa
Grau:	Artigo
Idioma:	eng
Publicado em:	Nature Publishing Group 2018
Assuntos:	Microcefalia / complica??es Microcefalia / fisiopatologia Infec??o pelo Zika virus / complica??es Infec??o pelo Zika virus / epidemiologia Zika virus / patogenicidade Meninges / anormalidades Sistema Nervoso Central / patologia Sistema Nervoso Central / anormalidades Encefalopatias / cong?nito Morte Perinatal Imuno-Histoqu?mica Brasil / epidemiologia
Acesso em linha:	http://patua.iec.gov.br//handle/iec/3058

id	ir-iec-3058
recordtype	dspace
spelling	ir-iec-30582019-08-19T19:14:20Z In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus Azevedo, Raimunda do Socorro da Silva Sousa, Jorge R. de Ara?jo, Marialva Tereza Ferreira de Martins Filho, Arnaldo J Alcantara, Bianca Nascimento de Araujo, Fernanda M. C Queiroz, Maria G. L. Cruz, Ana Cec?lia Ribeiro Vasconcelos, Beatriz H Baldez Chiang, Jannifer Oliveira Martins, L?via Caricio Casseb, Livia Medeiros Neves Silva, Eliana Vieira Pinto da Carvalho, Val?ria Lima Vasconcelos, Barbara C. Baldez Rodrigues, Sueli Guerreiro Oliveira, Consuelo Silva de Quaresma, Juarez A. S Vasconcelos, Pedro Fernando da Costa Microcefalia / complica??es Microcefalia / fisiopatologia Infec??o pelo Zika virus / complica??es Infec??o pelo Zika virus / epidemiologia Zika virus / patogenicidade Meninges / anormalidades Sistema Nervoso Central / patologia Sistema Nervoso Central / anormalidades Encefalopatias / cong?nito Morte Perinatal Imuno-Histoqu?mica Brasil / epidemiologia Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been proposed as ZIKV congenital syndrome. This study aimed to investigate the in situ immune response profle and mechanisms of neuronal cell damage in fatal Zika microcephaly cases. Brain tissue samples were collected from 15 cases, including 10 microcephalic ZIKV-positive neonates with fatal outcome and fve neonatal control favivirus-negative neonates that died due to other causes, but with preserved central nervous system (CNS) architecture. In microcephaly cases, the histopathological features of the tissue samples were characterized in three CNS areas (meninges, perivascular space, and parenchyma). The changes found were mainly calcifcation, necrosis, neuronophagy, gliosis, microglial nodules, and infammatory infltration of mononuclear cells. The in situ immune response against ZIKV in the CNS of newborns is complex. Despite the predominant expression of Th2 cytokines, other cytokines such as Th1, Th17, Treg, Th9, and Th22 are involved to a lesser extent, but are still likely to participate in the immunopathogenic mechanisms of neural disease in fatal cases of microcephaly caused by ZIKV. 2018-02-28T16:32:34Z 2018-02-28T16:32:34Z 2018 Artigo AZEVEDO, Raimunda do Socorro da Silva et al. In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus. Scientific Reports, v. 8, n. 1, p. 1-11, Jan. 2018. 2045-2322 http://patua.iec.gov.br//handle/iec/3058 10.1038/s41598-017-17765-5 eng Acesso Aberto application/pdf Nature Publishing Group
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Microcefalia / complica??es Microcefalia / fisiopatologia Infec??o pelo Zika virus / complica??es Infec??o pelo Zika virus / epidemiologia Zika virus / patogenicidade Meninges / anormalidades Sistema Nervoso Central / patologia Sistema Nervoso Central / anormalidades Encefalopatias / cong?nito Morte Perinatal Imuno-Histoqu?mica Brasil / epidemiologia
spellingShingle	Microcefalia / complica??es Microcefalia / fisiopatologia Infec??o pelo Zika virus / complica??es Infec??o pelo Zika virus / epidemiologia Zika virus / patogenicidade Meninges / anormalidades Sistema Nervoso Central / patologia Sistema Nervoso Central / anormalidades Encefalopatias / cong?nito Morte Perinatal Imuno-Histoqu?mica Brasil / epidemiologia Azevedo, Raimunda do Socorro da Silva In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
topic_facet	Microcefalia / complica??es Microcefalia / fisiopatologia Infec??o pelo Zika virus / complica??es Infec??o pelo Zika virus / epidemiologia Zika virus / patogenicidade Meninges / anormalidades Sistema Nervoso Central / patologia Sistema Nervoso Central / anormalidades Encefalopatias / cong?nito Morte Perinatal Imuno-Histoqu?mica Brasil / epidemiologia
description	Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been proposed as ZIKV congenital syndrome. This study aimed to investigate the in situ immune response profle and mechanisms of neuronal cell damage in fatal Zika microcephaly cases. Brain tissue samples were collected from 15 cases, including 10 microcephalic ZIKV-positive neonates with fatal outcome and fve neonatal control favivirus-negative neonates that died due to other causes, but with preserved central nervous system (CNS) architecture. In microcephaly cases, the histopathological features of the tissue samples were characterized in three CNS areas (meninges, perivascular space, and parenchyma). The changes found were mainly calcifcation, necrosis, neuronophagy, gliosis, microglial nodules, and infammatory infltration of mononuclear cells. The in situ immune response against ZIKV in the CNS of newborns is complex. Despite the predominant expression of Th2 cytokines, other cytokines such as Th1, Th17, Treg, Th9, and Th22 are involved to a lesser extent, but are still likely to participate in the immunopathogenic mechanisms of neural disease in fatal cases of microcephaly caused by ZIKV.
format	Artigo
author	Azevedo, Raimunda do Socorro da Silva
author2	Sousa, Jorge R. de Ara?jo, Marialva Tereza Ferreira de Martins Filho, Arnaldo J Alcantara, Bianca Nascimento de Araujo, Fernanda M. C Queiroz, Maria G. L. Cruz, Ana Cec?lia Ribeiro Vasconcelos, Beatriz H Baldez Chiang, Jannifer Oliveira Martins, L?via Caricio Casseb, Livia Medeiros Neves Silva, Eliana Vieira Pinto da Carvalho, Val?ria Lima Vasconcelos, Barbara C. Baldez Rodrigues, Sueli Guerreiro Oliveira, Consuelo Silva de Quaresma, Juarez A. S Vasconcelos, Pedro Fernando da Costa
author2Str	Sousa, Jorge R. de Ara?jo, Marialva Tereza Ferreira de Martins Filho, Arnaldo J Alcantara, Bianca Nascimento de Araujo, Fernanda M. C Queiroz, Maria G. L. Cruz, Ana Cec?lia Ribeiro Vasconcelos, Beatriz H Baldez Chiang, Jannifer Oliveira Martins, L?via Caricio Casseb, Livia Medeiros Neves Silva, Eliana Vieira Pinto da Carvalho, Val?ria Lima Vasconcelos, Barbara C. Baldez Rodrigues, Sueli Guerreiro Oliveira, Consuelo Silva de Quaresma, Juarez A. S Vasconcelos, Pedro Fernando da Costa
title	In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
title_short	In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
title_full	In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
title_fullStr	In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
title_full_unstemmed	In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
title_sort	in situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by zika virus
publisher	Nature Publishing Group
publishDate	2018
url	http://patua.iec.gov.br//handle/iec/3058
_version_	1717584372255686656
score	11.755432

In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

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