Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence

Cavalcante, Jos? Roosevelt; Pinheiro, Luiz Gonzaga Porto; Almeida, Paulo Roberto Carvalho de; Ferreira, M?rcia Val?ria Pitombeira; Cruz, Gizele Almada; Campelo, Thales Alves; Silva, Caroliny Soares; Lima, Luana Nepomuceno Gondim Costa; Oliveira, Bruno Masato Kitagawa de; Lima, Lara Mulato; Feitosa, Laura Magda Costa; Pinheiro, Agostinho C?mara; Frota, Cristiane Cunha

Artigo

Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence

OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the no...

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Autor principal:	Cavalcante, Jos? Roosevelt
Outros Autores:	Pinheiro, Luiz Gonzaga Porto, Almeida, Paulo Roberto Carvalho de, Ferreira, M?rcia Val?ria Pitombeira, Cruz, Gizele Almada, Campelo, Thales Alves, Silva, Caroliny Soares, Lima, Luana Nepomuceno Gondim Costa, Oliveira, Bruno Masato Kitagawa de, Lima, Lara Mulato, Feitosa, Laura Magda Costa, Pinheiro, Agostinho C?mara, Frota, Cristiane Cunha
Grau:	Artigo
Idioma:	eng
Publicado em:	Faculdade de Medicina / USP 2018
Assuntos:	Papillomaviridae / patogenicidade Infec??es por Papillomavirus / patogenicidade Papillomavirus Humano 11 / isolamento & purifica??o Papillomavirus Humano 6 / isolamento & purifica??o Neoplasias da Mama Carcinog?nese / patologia Coinfec??o
Acesso em linha:	http://patua.iec.gov.br//handle/iec/3525

id	ir-iec-3525
recordtype	dspace
spelling	ir-iec-35252018-11-13T14:09:14Z Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence Cavalcante, Jos? Roosevelt Pinheiro, Luiz Gonzaga Porto Almeida, Paulo Roberto Carvalho de Ferreira, M?rcia Val?ria Pitombeira Cruz, Gizele Almada Campelo, Thales Alves Silva, Caroliny Soares Lima, Luana Nepomuceno Gondim Costa Oliveira, Bruno Masato Kitagawa de Lima, Lara Mulato Feitosa, Laura Magda Costa Pinheiro, Agostinho C?mara Frota, Cristiane Cunha Papillomaviridae / patogenicidade Infec??es por Papillomavirus / patogenicidade Papillomavirus Humano 11 / isolamento & purifica??o Papillomavirus Humano 6 / isolamento & purifica??o Neoplasias da Mama Carcinog?nese / patologia Coinfec??o OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region. RESULTS: Human papillomavirus DNA was detected in 51 (49.5%) breast carcinoma samples and 15 (15.8%) normal breast samples (p<0.0001). Human papillomavirus genotypes 6 and 11 were identified in 15.2% of all samples. CONCLUSIONS: The high frequency of human papillomavirus infection in breast cancer samples indicates a potential role of this virus in breast carcinogenesis in the studied participants. 2018-11-13T13:30:35Z 2018-11-13T13:30:35Z 2018 Artigo CAVALCANTE, Jos? Roosevelt et al. Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence. Clinics, v. 73, e465, p. 1-6, Oct. 2018. 1807-5932 http://patua.iec.gov.br//handle/iec/3525 10.6061/clinics/2018/e465 eng Acesso Aberto application/pdf Faculdade de Medicina / USP
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Papillomaviridae / patogenicidade Infec??es por Papillomavirus / patogenicidade Papillomavirus Humano 11 / isolamento & purifica??o Papillomavirus Humano 6 / isolamento & purifica??o Neoplasias da Mama Carcinog?nese / patologia Coinfec??o
spellingShingle	Papillomaviridae / patogenicidade Infec??es por Papillomavirus / patogenicidade Papillomavirus Humano 11 / isolamento & purifica??o Papillomavirus Humano 6 / isolamento & purifica??o Neoplasias da Mama Carcinog?nese / patologia Coinfec??o Cavalcante, Jos? Roosevelt Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
topic_facet	Papillomaviridae / patogenicidade Infec??es por Papillomavirus / patogenicidade Papillomavirus Humano 11 / isolamento & purifica??o Papillomavirus Humano 6 / isolamento & purifica??o Neoplasias da Mama Carcinog?nese / patologia Coinfec??o
description	OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region. RESULTS: Human papillomavirus DNA was detected in 51 (49.5%) breast carcinoma samples and 15 (15.8%) normal breast samples (p<0.0001). Human papillomavirus genotypes 6 and 11 were identified in 15.2% of all samples. CONCLUSIONS: The high frequency of human papillomavirus infection in breast cancer samples indicates a potential role of this virus in breast carcinogenesis in the studied participants.
format	Artigo
author	Cavalcante, Jos? Roosevelt
author2	Pinheiro, Luiz Gonzaga Porto Almeida, Paulo Roberto Carvalho de Ferreira, M?rcia Val?ria Pitombeira Cruz, Gizele Almada Campelo, Thales Alves Silva, Caroliny Soares Lima, Luana Nepomuceno Gondim Costa Oliveira, Bruno Masato Kitagawa de Lima, Lara Mulato Feitosa, Laura Magda Costa Pinheiro, Agostinho C?mara Frota, Cristiane Cunha
author2Str	Pinheiro, Luiz Gonzaga Porto Almeida, Paulo Roberto Carvalho de Ferreira, M?rcia Val?ria Pitombeira Cruz, Gizele Almada Campelo, Thales Alves Silva, Caroliny Soares Lima, Luana Nepomuceno Gondim Costa Oliveira, Bruno Masato Kitagawa de Lima, Lara Mulato Feitosa, Laura Magda Costa Pinheiro, Agostinho C?mara Frota, Cristiane Cunha
title	Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
title_short	Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
title_full	Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
title_fullStr	Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
title_full_unstemmed	Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
title_sort	association of breast cancer with human papillomavirus (hpv) infection in northeast brazil: molecular evidence
publisher	Faculdade de Medicina / USP
publishDate	2018
url	http://patua.iec.gov.br//handle/iec/3525
_version_	1717584506654818304
score	11.755432

Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence

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