A novel hepacivirus in wild rodents from South America
The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identif...
| Autor principal: | Souza, William Marciel de |
|---|---|
| Outros Autores: | Fumagalli, Marc?lio Jorge, Santos Jr, Gilberto Sabino, Maia, Felipe Gon?alves Motta, Modha, Sejal, Nunes, M?rcio Roberto Teixeira, Murcia, Pablo Ramiro, Figueiredo, Luiz Tadeu Moraes |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3633 |
| Resumo: |
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The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the
family Flaviviridae. Several hepaciviruses have been identified in different mammals, including
multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus
has been identified in the South American continent. Here, we describe an unknown hepacivirus
discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes,
Necromys lasiurus, and Mus musculus from S?o Paulo State, Brazil. Molecular detection of this novel
hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the
first identification of hepavivirus in sigmondonine rodents and in rodents from South America.
In sum, our results expand the host range, viral diversity, and geographical distribution of the
Hepacivirus genus. |