A novel hepacivirus in wild rodents from South America
The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identif...
| Autor principal: | Souza, William Marciel de |
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| Outros Autores: | Fumagalli, Marc?lio Jorge, Santos Jr, Gilberto Sabino, Maia, Felipe Gon?alves Motta, Modha, Sejal, Nunes, M?rcio Roberto Teixeira, Murcia, Pablo Ramiro, Figueiredo, Luiz Tadeu Moraes |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3633 |
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ir-iec-3633 |
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ir-iec-36332019-04-09T16:52:06Z A novel hepacivirus in wild rodents from South America Souza, William Marciel de Fumagalli, Marc?lio Jorge Santos Jr, Gilberto Sabino Maia, Felipe Gon?alves Motta Modha, Sejal Nunes, M?rcio Roberto Teixeira Murcia, Pablo Ramiro Figueiredo, Luiz Tadeu Moraes Hepacivirus / isolamento & purifica??o Hepatite C / patologia Flaviviridae / patogenicidade Arvicolinae / virologia Camundongos Doen?as dos Roedores / virologia The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from S?o Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus. This research was funded by Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo, Brazil (Grant number No. 13/14929-1, and Scholarships No. 12/24150-9; 15/05778-5; 17/13981-0; 16/01414-1; 08/06411-4; 11/06810-9; 11/22663-6; 16/02568-2). PRM was supported by the Medical Research Council of the United Kingdom (Grant MC_UU_120/14/9). 2019-04-09T16:10:03Z 2019-04-09T16:10:03Z 2019 Artigo SOUZA, William Marciel de et al. A novel hepacivirus in wild rodents from South America. Viruses. v. 11, n. 3, e297, p. 1-7, Mar. 2019. 1999-4915 http://patua.iec.gov.br//handle/iec/3633 10.3390/v11030297 eng Acesso Aberto application/pdf MDPI |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Hepacivirus / isolamento & purifica??o Hepatite C / patologia Flaviviridae / patogenicidade Arvicolinae / virologia Camundongos Doen?as dos Roedores / virologia |
| spellingShingle |
Hepacivirus / isolamento & purifica??o Hepatite C / patologia Flaviviridae / patogenicidade Arvicolinae / virologia Camundongos Doen?as dos Roedores / virologia Souza, William Marciel de A novel hepacivirus in wild rodents from South America |
| topic_facet |
Hepacivirus / isolamento & purifica??o Hepatite C / patologia Flaviviridae / patogenicidade Arvicolinae / virologia Camundongos Doen?as dos Roedores / virologia |
| description |
The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the
family Flaviviridae. Several hepaciviruses have been identified in different mammals, including
multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus
has been identified in the South American continent. Here, we describe an unknown hepacivirus
discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes,
Necromys lasiurus, and Mus musculus from S?o Paulo State, Brazil. Molecular detection of this novel
hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the
first identification of hepavivirus in sigmondonine rodents and in rodents from South America.
In sum, our results expand the host range, viral diversity, and geographical distribution of the
Hepacivirus genus. |
| format |
Artigo |
| author |
Souza, William Marciel de |
| author2 |
Fumagalli, Marc?lio Jorge Santos Jr, Gilberto Sabino Maia, Felipe Gon?alves Motta Modha, Sejal Nunes, M?rcio Roberto Teixeira Murcia, Pablo Ramiro Figueiredo, Luiz Tadeu Moraes |
| author2Str |
Fumagalli, Marc?lio Jorge Santos Jr, Gilberto Sabino Maia, Felipe Gon?alves Motta Modha, Sejal Nunes, M?rcio Roberto Teixeira Murcia, Pablo Ramiro Figueiredo, Luiz Tadeu Moraes |
| title |
A novel hepacivirus in wild rodents from South America |
| title_short |
A novel hepacivirus in wild rodents from South America |
| title_full |
A novel hepacivirus in wild rodents from South America |
| title_fullStr |
A novel hepacivirus in wild rodents from South America |
| title_full_unstemmed |
A novel hepacivirus in wild rodents from South America |
| title_sort |
novel hepacivirus in wild rodents from south america |
| publisher |
MDPI |
| publishDate |
2019 |
| url |
http://patua.iec.gov.br//handle/iec/3633 |
| _version_ |
1717584350046846976 |
| score |
11.755432 |