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Artigo
Disease activity Score 28 in patients with Chikungunya virus infection
Objective: This study aims to evaluate different parameters for determining the inflammatory activity in patients with Chikungunya. Patients and methods: An observational, cross-sectional, descriptive, and analytical study was con ducted with 56 patients from May 2018 to June 2020. Seven independent...
Autor principal: | SÁ, Angela Beatriz de |
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Outros Autores: | GOMES, Anna Carolina Padilha Castro |
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2023
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oai:https:--bdm.ufpa.br:8443:prefix-54932023-09-22T03:06:48Z Disease activity Score 28 in patients with Chikungunya virus infection SÁ, Angela Beatriz de GOMES, Anna Carolina Padilha Castro CALDAS, Cezar Augusto Muniz http://lattes.cnpq.br/0204781177047305 SOUSA, Rita Catarina Medeiros http://lattes.cnpq.br/3560941703812539 https://orcid.org/0000-0002-1141-1281 https://orcid.org/0000-0002-8330-6667 Chikungunya fever Arbovirus infections Arthritis Arthralgia Disease activity CNPQ::CIENCIAS DA SAUDE::MEDICINA Objective: This study aims to evaluate different parameters for determining the inflammatory activity in patients with Chikungunya. Patients and methods: An observational, cross-sectional, descriptive, and analytical study was con ducted with 56 patients from May 2018 to June 2020. Seven independent variables were evaluated [pain in 28 joints, oedema in 28 joints, erythrocyte sedimentation rate, global health assessment, Disease Ac tivity Score 28 (DAS28), pain in 64 joints and oedema in 64 joints] and analysed with a regression mod el to determine their influence on patient satisfaction (dependent variable). Results: All studied variables had a significant influence on patient satisfaction, especially the DAS28. However, the agreement between patient satisfaction and the DAS28 was poor (kappa = 0.2). Thus, new cut-off points were established for the DAS28. Compared to the traditional cut-off points used in rheumatoid arthritis, the new cut-off points increased the accuracy of the DAS28 from 37.5% to 51.8%. Conclusions: This study contributes to the literature by presenting the DAS28 as a potentially useful instrument in patients with Chikungunya and using cut-off points adjusted for this population. The results can serve as a reference for future studies with larger sample sizes, which would allow more definitive conclusions. 2023-04-03T13:19:58Z 2023-04-03T13:19:58Z 2022 Trabalho de Conclusão de Curso - Graduação - Artigo SÁ, Angela Beatriz de; GOMES, Anna Carolina Padilha Castro. Disease activity Score 28 in patients with Chikungunya vírus infection. Infectious diseases & tropical medicine. [S. l.], v. 8, e 794, p-1-5, jan. 2022. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/5493. Acesso em: https://bdm.ufpa.br:8443/jspui/handle/prefix/5493 Acesso Aberto Disponível na internet via correio eletrônico: bibsaude@ufpa.br |
institution |
Biblioteca Digital de Monografias - UFPA |
collection |
MonografiaUFPA |
topic |
Chikungunya fever Arbovirus infections Arthritis Arthralgia Disease activity CNPQ::CIENCIAS DA SAUDE::MEDICINA |
spellingShingle |
Chikungunya fever Arbovirus infections Arthritis Arthralgia Disease activity CNPQ::CIENCIAS DA SAUDE::MEDICINA SÁ, Angela Beatriz de Disease activity Score 28 in patients with Chikungunya virus infection |
topic_facet |
Chikungunya fever Arbovirus infections Arthritis Arthralgia Disease activity CNPQ::CIENCIAS DA SAUDE::MEDICINA |
description |
Objective: This study aims to evaluate different parameters for determining the inflammatory activity in patients with Chikungunya. Patients and methods: An observational, cross-sectional, descriptive, and analytical study was con ducted with 56 patients from May 2018 to June 2020. Seven independent variables were evaluated [pain in 28 joints, oedema in 28 joints, erythrocyte sedimentation rate, global health assessment, Disease Ac tivity Score 28 (DAS28), pain in 64 joints and oedema in 64 joints] and analysed with a regression mod el to determine their influence on patient satisfaction (dependent variable). Results: All studied variables had a significant influence on patient satisfaction, especially the DAS28. However, the agreement between patient satisfaction and the DAS28 was poor (kappa = 0.2). Thus, new cut-off points were established for the DAS28. Compared to the traditional cut-off points used in rheumatoid arthritis, the new cut-off points increased the accuracy of the DAS28 from 37.5% to 51.8%. Conclusions: This study contributes to the literature by presenting the DAS28 as a potentially useful instrument in patients with Chikungunya and using cut-off points adjusted for this population. The results can serve as a reference for future studies with larger sample sizes, which would allow more definitive conclusions. |
author_additional |
CALDAS, Cezar Augusto Muniz |
author_additionalStr |
CALDAS, Cezar Augusto Muniz |
format |
Artigo |
author |
SÁ, Angela Beatriz de |
author2 |
GOMES, Anna Carolina Padilha Castro |
author2Str |
GOMES, Anna Carolina Padilha Castro |
title |
Disease activity Score 28 in patients with Chikungunya virus infection |
title_short |
Disease activity Score 28 in patients with Chikungunya virus infection |
title_full |
Disease activity Score 28 in patients with Chikungunya virus infection |
title_fullStr |
Disease activity Score 28 in patients with Chikungunya virus infection |
title_full_unstemmed |
Disease activity Score 28 in patients with Chikungunya virus infection |
title_sort |
disease activity score 28 in patients with chikungunya virus infection |
publishDate |
2023 |
url |
https://bdm.ufpa.br:8443/jspui/handle/prefix/5493 |
_version_ |
1787238438273024000 |
score |
11.753896 |