Artigo

Disease activity Score 28 in patients with Chikungunya virus infection

Objective: This study aims to evaluate different parameters for determining the inflammatory activity in patients with Chikungunya. Patients and methods: An observational, cross-sectional, descriptive, and analytical study was con ducted with 56 patients from May 2018 to June 2020. Seven independent...

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Autor principal: SÁ, Angela Beatriz de
Outros Autores: GOMES, Anna Carolina Padilha Castro
Grau: Artigo
Publicado em: 2023
Assuntos:
Chikungunya fever
Arbovirus infections
Arthritis
Arthralgia
Disease activity
CNPQ::CIENCIAS DA SAUDE::MEDICINA
Acesso em linha: https://bdm.ufpa.br:8443/jspui/handle/prefix/5493
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recordtype dspace
spelling oai:https:--bdm.ufpa.br:8443:prefix-54932023-09-22T03:06:48Z Disease activity Score 28 in patients with Chikungunya virus infection SÁ, Angela Beatriz de GOMES, Anna Carolina Padilha Castro CALDAS, Cezar Augusto Muniz http://lattes.cnpq.br/0204781177047305 SOUSA, Rita Catarina Medeiros http://lattes.cnpq.br/3560941703812539 https://orcid.org/0000-0002-1141-1281 https://orcid.org/0000-0002-8330-6667 Chikungunya fever Arbovirus infections Arthritis Arthralgia Disease activity CNPQ::CIENCIAS DA SAUDE::MEDICINA Objective: This study aims to evaluate different parameters for determining the inflammatory activity in patients with Chikungunya. Patients and methods: An observational, cross-sectional, descriptive, and analytical study was con ducted with 56 patients from May 2018 to June 2020. Seven independent variables were evaluated [pain in 28 joints, oedema in 28 joints, erythrocyte sedimentation rate, global health assessment, Disease Ac tivity Score 28 (DAS28), pain in 64 joints and oedema in 64 joints] and analysed with a regression mod el to determine their influence on patient satisfaction (dependent variable). Results: All studied variables had a significant influence on patient satisfaction, especially the DAS28. However, the agreement between patient satisfaction and the DAS28 was poor (kappa = 0.2). Thus, new cut-off points were established for the DAS28. Compared to the traditional cut-off points used in rheumatoid arthritis, the new cut-off points increased the accuracy of the DAS28 from 37.5% to 51.8%. Conclusions: This study contributes to the literature by presenting the DAS28 as a potentially useful instrument in patients with Chikungunya and using cut-off points adjusted for this population. The results can serve as a reference for future studies with larger sample sizes, which would allow more definitive conclusions. 2023-04-03T13:19:58Z 2023-04-03T13:19:58Z 2022 Trabalho de Conclusão de Curso - Graduação - Artigo SÁ, Angela Beatriz de; GOMES, Anna Carolina Padilha Castro. Disease activity Score 28 in patients with Chikungunya vírus infection. Infectious diseases & tropical medicine. [S. l.], v. 8, e 794, p-1-5, jan. 2022. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/5493. Acesso em: https://bdm.ufpa.br:8443/jspui/handle/prefix/5493 Acesso Aberto Disponível na internet via correio eletrônico: bibsaude@ufpa.br
institution Biblioteca Digital de Monografias - UFPA
collection MonografiaUFPA
topic Chikungunya fever
Arbovirus infections
Arthritis
Arthralgia
Disease activity
CNPQ::CIENCIAS DA SAUDE::MEDICINA
spellingShingle Chikungunya fever
Arbovirus infections
Arthritis
Arthralgia
Disease activity
CNPQ::CIENCIAS DA SAUDE::MEDICINA
SÁ, Angela Beatriz de
Disease activity Score 28 in patients with Chikungunya virus infection
topic_facet Chikungunya fever
Arbovirus infections
Arthritis
Arthralgia
Disease activity
CNPQ::CIENCIAS DA SAUDE::MEDICINA
description Objective: This study aims to evaluate different parameters for determining the inflammatory activity in patients with Chikungunya. Patients and methods: An observational, cross-sectional, descriptive, and analytical study was con ducted with 56 patients from May 2018 to June 2020. Seven independent variables were evaluated [pain in 28 joints, oedema in 28 joints, erythrocyte sedimentation rate, global health assessment, Disease Ac tivity Score 28 (DAS28), pain in 64 joints and oedema in 64 joints] and analysed with a regression mod el to determine their influence on patient satisfaction (dependent variable). Results: All studied variables had a significant influence on patient satisfaction, especially the DAS28. However, the agreement between patient satisfaction and the DAS28 was poor (kappa = 0.2). Thus, new cut-off points were established for the DAS28. Compared to the traditional cut-off points used in rheumatoid arthritis, the new cut-off points increased the accuracy of the DAS28 from 37.5% to 51.8%. Conclusions: This study contributes to the literature by presenting the DAS28 as a potentially useful instrument in patients with Chikungunya and using cut-off points adjusted for this population. The results can serve as a reference for future studies with larger sample sizes, which would allow more definitive conclusions.
author_additional CALDAS, Cezar Augusto Muniz
author_additionalStr CALDAS, Cezar Augusto Muniz
format Artigo
author SÁ, Angela Beatriz de
author2 GOMES, Anna Carolina Padilha Castro
author2Str GOMES, Anna Carolina Padilha Castro
title Disease activity Score 28 in patients with Chikungunya virus infection
title_short Disease activity Score 28 in patients with Chikungunya virus infection
title_full Disease activity Score 28 in patients with Chikungunya virus infection
title_fullStr Disease activity Score 28 in patients with Chikungunya virus infection
title_full_unstemmed Disease activity Score 28 in patients with Chikungunya virus infection
title_sort disease activity score 28 in patients with chikungunya virus infection
publishDate 2023
url https://bdm.ufpa.br:8443/jspui/handle/prefix/5493
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score 11.753896

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