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Trabalho de Conclusão de Curso - Graduação
Perfil epidemiológico dos pacientes atendidos com anomalias da diferenciação sexual em serviço de referência na região norte do Brasil no período de 2006 à 2018
INTRODUCTION: Anomalies of sexual differentiation (ADS) are characterized by the occurrence of an atypical development of chromosomal, gonadal or anatomical sex. It concerns cases of genital ambiguity, these are usually observed soon after birth, as it is not possible to identify the external...
Autor principal: | SILVA, Joissilane Rodrigues da |
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Outros Autores: | SILVA, Raquel Cardoso da |
Grau: | Trabalho de Conclusão de Curso - Graduação |
Publicado em: |
2023
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Assuntos: | |
Acesso em linha: |
https://bdm.ufpa.br:8443/jspui/handle/prefix/6058 |
Resumo: |
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INTRODUCTION: Anomalies of sexual differentiation (ADS) are characterized by the
occurrence of an atypical development of chromosomal, gonadal or anatomical sex. It concerns
cases of genital ambiguity, these are usually observed soon after birth, as it is not possible to
identify the external genitalia as male or female. Requiring a quick investigation and at the same
time needs to involve professionals from different areas. OBJECTIVES: This study aimed to
analyze the clinical and epidemiological aspects of sexual differentiation anomalies in patients
attended at a referral hospital in the state of Pará from 2006 to 2018. METHOD: This is a
descriptive, retrospective observational study. RESULTS: From the present study identified a
total of 60 cases of ADS, a frequency of 20% of disease in the population referred for
investigation in this service, most children did not have birth registration with identification of
sex (38.33%), were in the first year of life (53.33%), from the interior of the state of Pará or
other states (53.33%), with karyotype 46, XX (46.67%), having as main manifestations for the
karyotype Congenital adrenal hyperplasia (38.33%) and disorders of gonadal determination
(30.00%) for karyotype 46, XY, located mainly between stages 3 and 5 of Prader (68.33%),
revealed that 14 patients (23.33%) had a history of ADS in the family and 15% reported having
used some medication during pregnancy. About 60% of the children were diagnosed in the
delivery room, 68.33% reported by the doctor, a little more than 61% of the parents registered
their children even without an investigation, only 16.66% had care at the reference center until
the 28 days of birth. Taking as a research bias, the deficiency of a computerized service in the
outpatient services in the reference service and lack of some data recorded in the medical
records. CONCLUSION: The frequency of cases was considered high when compared to the
other studies. Most were from the interior of Pará and other states. The most associated risk
factors were medication use during pregnancy and cases of ADS in the family. The time in
which a child born with ADS took to the realization of the first consultation in the service was
in average of 2 years and 8 months. The most frequent nosological entity was congenital adrenal
hyperplasia. |