Congenital Zika syndrome is associated with maternal protein malnutrition
Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relev...
| Autor principal: | Barbeito-Andr?s, J |
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| Outros Autores: | Pezzuto, P, Higa, L. M, Dias, A. A, Vasconcelos, J. M, Santos, T. M. P, Ferreira, J. C. C. G, Ferreira, R. O, Dutra, F. F, Rossi, A. D, Barbosa, R. V, Amorim, C. K. N, Souza, M. P. C de, Chimelli, L, Aguiar, R. S, Gonzalez, P. N, Lara, F. A, Castro, M. C, Moln?r, Z, Lopes, R. T, Bozza, M. T, Vianez J?nior, Jo?o L?dio da Silva Gon?alves, Barbeito, C. G, Cuervo, P, Bellio, M, Tanuri, A, Garcez, P. P |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/4060 |
| Resumo: |
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Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known
as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting
that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the
emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between
undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent
pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found
that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and
embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq
analysis reveals gene expression deregulation required for brain development in infected low-protein progeny.
These results suggest that maternal protein malnutrition increases susceptibility to CZS. |