Congenital Zika syndrome is associated with maternal protein malnutrition

Barbeito-Andr?s, J; Pezzuto, P; Higa, L. M; Dias, A. A; Vasconcelos, J. M; Santos, T. M. P; Ferreira, J. C. C. G; Ferreira, R. O; Dutra, F. F; Rossi, A. D; Barbosa, R. V; Amorim, C. K. N; Souza, M. P. C de; Chimelli, L; Aguiar, R. S; Gonzalez, P. N; Lara, F. A; Castro, M. C; Moln?r, Z; Lopes, R. T; Bozza, M. T; Vianez J?nior, Jo?o L?dio da Silva Gon?alves; Barbeito, C. G; Cuervo, P; Bellio, M; Tanuri, A; Garcez, P. P

Artigo

Congenital Zika syndrome is associated with maternal protein malnutrition

Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relev...

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Autor principal:	Barbeito-Andr?s, J
Outros Autores:	Pezzuto, P, Higa, L. M, Dias, A. A, Vasconcelos, J. M, Santos, T. M. P, Ferreira, J. C. C. G, Ferreira, R. O, Dutra, F. F, Rossi, A. D, Barbosa, R. V, Amorim, C. K. N, Souza, M. P. C de, Chimelli, L, Aguiar, R. S, Gonzalez, P. N, Lara, F. A, Castro, M. C, Moln?r, Z, Lopes, R. T, Bozza, M. T, Vianez J?nior, Jo?o L?dio da Silva Gon?alves, Barbeito, C. G, Cuervo, P, Bellio, M, Tanuri, A, Garcez, P. P
Grau:	Artigo
Idioma:	eng
Publicado em:	American Association for the Advancement of Science 2020
Assuntos:	Zika virus / patogenicidade Microcefalia Gravidez / gen?tica Defici?ncia de Prote?na
Acesso em linha:	http://patua.iec.gov.br//handle/iec/4060

id	ir-iec-4060
recordtype	dspace
spelling	ir-iec-40602020-02-28T14:28:53Z Congenital Zika syndrome is associated with maternal protein malnutrition Barbeito-Andr?s, J Pezzuto, P Higa, L. M Dias, A. A Vasconcelos, J. M Santos, T. M. P Ferreira, J. C. C. G Ferreira, R. O Dutra, F. F Rossi, A. D Barbosa, R. V Amorim, C. K. N Souza, M. P. C de Chimelli, L Aguiar, R. S Gonzalez, P. N Lara, F. A Castro, M. C Moln?r, Z Lopes, R. T Bozza, M. T Vianez J?nior, Jo?o L?dio da Silva Gon?alves Barbeito, C. G Cuervo, P Bellio, M Tanuri, A Garcez, P. P Zika virus / patogenicidade Microcefalia Gravidez / gen?tica Defici?ncia de Prote?na Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS. MRC Zika Rapid Response Grant (MC_PC_15102), FAPERJ (E_03/2017E_03/2017), the Brazilian Ministry of Health (DSAST/SVS 25380.001612/2017-70), and the AAPA Professional Development Grant 2020-02-21T19:09:35Z 2020-02-21T19:09:35Z 2020 Artigo BARBEITO-ANDR?S, J. et al. Congenital Zika syndrome is associated with maternal protein malnutrition. Science Advances, v. 6, n. 2, p. 1-12, Jan. 2020. 2375-2548 http://patua.iec.gov.br//handle/iec/4060 10.1126/sciadv.aaw6284 eng Acesso Aberto application/pdf American Association for the Advancement of Science
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Zika virus / patogenicidade Microcefalia Gravidez / gen?tica Defici?ncia de Prote?na
spellingShingle	Zika virus / patogenicidade Microcefalia Gravidez / gen?tica Defici?ncia de Prote?na Barbeito-Andr?s, J Congenital Zika syndrome is associated with maternal protein malnutrition
topic_facet	Zika virus / patogenicidade Microcefalia Gravidez / gen?tica Defici?ncia de Prote?na
description	Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS.
format	Artigo
author	Barbeito-Andr?s, J
author2	Pezzuto, P Higa, L. M Dias, A. A Vasconcelos, J. M Santos, T. M. P Ferreira, J. C. C. G Ferreira, R. O Dutra, F. F Rossi, A. D Barbosa, R. V Amorim, C. K. N Souza, M. P. C de Chimelli, L Aguiar, R. S Gonzalez, P. N Lara, F. A Castro, M. C Moln?r, Z Lopes, R. T Bozza, M. T Vianez J?nior, Jo?o L?dio da Silva Gon?alves Barbeito, C. G Cuervo, P Bellio, M Tanuri, A Garcez, P. P
author2Str	Pezzuto, P Higa, L. M Dias, A. A Vasconcelos, J. M Santos, T. M. P Ferreira, J. C. C. G Ferreira, R. O Dutra, F. F Rossi, A. D Barbosa, R. V Amorim, C. K. N Souza, M. P. C de Chimelli, L Aguiar, R. S Gonzalez, P. N Lara, F. A Castro, M. C Moln?r, Z Lopes, R. T Bozza, M. T Vianez J?nior, Jo?o L?dio da Silva Gon?alves Barbeito, C. G Cuervo, P Bellio, M Tanuri, A Garcez, P. P
title	Congenital Zika syndrome is associated with maternal protein malnutrition
title_short	Congenital Zika syndrome is associated with maternal protein malnutrition
title_full	Congenital Zika syndrome is associated with maternal protein malnutrition
title_fullStr	Congenital Zika syndrome is associated with maternal protein malnutrition
title_full_unstemmed	Congenital Zika syndrome is associated with maternal protein malnutrition
title_sort	congenital zika syndrome is associated with maternal protein malnutrition
publisher	American Association for the Advancement of Science
publishDate	2020
url	http://patua.iec.gov.br//handle/iec/4060
_version_	1717584536470028288
score	11.755432

Congenital Zika syndrome is associated with maternal protein malnutrition

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