Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon
Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Par...
| Autor principal: | Oliveira, Consuelo Silva de |
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| Outros Autores: | Matos, Haroldo Jos? de, Ramos, Francisco L?zio de Paula, Pinto, Ana Yec? das Neves, Graim, Priscila Nathyelly dos S, Guimar?es, Vivianne de Paula R, Gomes, Luna Tha?s S, Serra, Emilene M. F, Cruz, Ana Cec?lia Ribeiro, Leal, Alessandra, Henriques, Daniele Freitas, Lima, Juliana A, Anjos, Maura V, Pinto, Eliana Vieira Pinto da, Souza, Alana W. de, Vasconcelos, Pedro Fernando da Costa |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Pan American Health Organization
2020
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/4177 |
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ir-iec-4177 |
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ir-iec-41772020-09-23T12:45:05Z Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon Oliveira, Consuelo Silva de Matos, Haroldo Jos? de Ramos, Francisco L?zio de Paula Pinto, Ana Yec? das Neves Graim, Priscila Nathyelly dos S Guimar?es, Vivianne de Paula R Gomes, Luna Tha?s S Serra, Emilene M. F Cruz, Ana Cec?lia Ribeiro Leal, Alessandra Henriques, Daniele Freitas Lima, Juliana A Anjos, Maura V Pinto, Eliana Vieira Pinto da Souza, Alana W. de Vasconcelos, Pedro Fernando da Costa Zika virus / patogenicidade Infec??o por Zika virus Microcefalia / gen?tica Gravidez Complica??es na Gravidez Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Par?, Brazil, from October 2015 to December 2017. Results. A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR during gestation. Conclusions. Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage, which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/ or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection. Financial support provided by the Evandro Chagas Institute. 2020-09-23T12:09:32Z 2020-09-23T12:09:32Z 2020 Artigo OLIVEIRA, Consuelo Silva de et al. Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon. Revista Panamericana de Salud P?blica, v. 44, p. 1-5, 2020. 1680-5348 http://patua.iec.gov.br//handle/iec/4177 10.26633.RPSP.2020.116 eng Acesso Aberto application/pdf Pan American Health Organization |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Zika virus / patogenicidade Infec??o por Zika virus Microcefalia / gen?tica Gravidez Complica??es na Gravidez |
| spellingShingle |
Zika virus / patogenicidade Infec??o por Zika virus Microcefalia / gen?tica Gravidez Complica??es na Gravidez Oliveira, Consuelo Silva de Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon |
| topic_facet |
Zika virus / patogenicidade Infec??o por Zika virus Microcefalia / gen?tica Gravidez Complica??es na Gravidez |
| description |
Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during
pregnancy.
Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during
pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Par?, Brazil, from October
2015 to December 2017.
Results. A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates
infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR
during gestation.
Conclusions. Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage,
which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/
or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection. |
| format |
Artigo |
| author |
Oliveira, Consuelo Silva de |
| author2 |
Matos, Haroldo Jos? de Ramos, Francisco L?zio de Paula Pinto, Ana Yec? das Neves Graim, Priscila Nathyelly dos S Guimar?es, Vivianne de Paula R Gomes, Luna Tha?s S Serra, Emilene M. F Cruz, Ana Cec?lia Ribeiro Leal, Alessandra Henriques, Daniele Freitas Lima, Juliana A Anjos, Maura V Pinto, Eliana Vieira Pinto da Souza, Alana W. de Vasconcelos, Pedro Fernando da Costa |
| author2Str |
Matos, Haroldo Jos? de Ramos, Francisco L?zio de Paula Pinto, Ana Yec? das Neves Graim, Priscila Nathyelly dos S Guimar?es, Vivianne de Paula R Gomes, Luna Tha?s S Serra, Emilene M. F Cruz, Ana Cec?lia Ribeiro Leal, Alessandra Henriques, Daniele Freitas Lima, Juliana A Anjos, Maura V Pinto, Eliana Vieira Pinto da Souza, Alana W. de Vasconcelos, Pedro Fernando da Costa |
| title |
Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon |
| title_short |
Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon |
| title_full |
Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon |
| title_fullStr |
Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon |
| title_full_unstemmed |
Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon |
| title_sort |
risk of zika virus-associated birth defects in congenital confirmed cases in the brazilian amazon |
| publisher |
Pan American Health Organization |
| publishDate |
2020 |
| url |
http://patua.iec.gov.br//handle/iec/4177 |
| _version_ |
1717584455791542272 |
| score |
11.755432 |