Juvenile Systemic Lupus Erythematosus (JSLE) is an inflammatory disease onset generalized
chronic, autoimmune and multifactorial, culminating with the production of autoantibodies to
nuclear antigens, resulting in a range of clinical manifestations, often of a more serious when
there is involvement of the central nervous system and kidney, the latter called Lupus
Nephritis (LN). This study soughtto identifytheclinical and epidemiological profileof patients
with JSLEandanalyzethe factors associated withLNforcasesunder 16 years at Santa Casa de
Misericordia do Para (FSCMPA), from January 2006 to January 2011. For this, we carried out
a retrospective, descriptive and analytical, with a review of 20 charts of patients hospitalized
with JSLE and / or attended the outpatient clinics of Nephrology and Rheumatology
Children's FSCMPA, 17 of which were LN. TheFisher exact testand chisquare
contingencywere usedtodeterminethe variablesassociated withtheNL, withsignificantvalues
ofp≤0.05. The most common age range was 9 to 12 years (75%) and females were most
affected (95%). The clinical manifestations most prevalent were: arthralgia (85%), followed
by skin rash and photosensitivity malar (60%). The laboratory change was detected over the
normochromic normocytic anemia (65%) and positivity of ANA was observed in all patients.
The oral steroids were used as the main treatment, being employed in all patients, whereas in
half of them were required pulse. The SLEDAI score showed higher severity in 75% of
patients when applied to a first evaluation, from mild to moderate category for the last
evaluation in 95% of cases. Sixtysix percent of patients had renal involvement at diagnosis.
Edema (70.6%) and alteration of urinalysis (64.7%) were the most frequent renal
manifestations, although the renal histological injury was the most prevalent type IV of the
World Health Organization (WHO) changed. The largest number of diagnostic criteria (> 4)
had a positive association (P ≤ 0.05) with the LN being appointed as the only risk factor.
Among the many obstacles to the investigation of these patients is the small number of cases
in a single center and the lack of a national and international consensus about its
characteristics and clinical treatment, necessitating the need for further studies.
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